We have successfully demonstrated that learning to use a cortically-controlled BMI to perform a complex, sequential task is possible in chronically amputated animals. This is significant as it is known that the motor cortex undergoes reorganization following amputation and thus has clinical implications for human amputees17,18,19,20,21,22,23,24,25,26. We have also demonstrated here the possibility of using ipsilateral cortex of a chronic amputee to successfully perform a BMI task and compared the dynamics of its plastic changes with contralateral networks. This has implications on developing BMIs for lateralized cortical deficit, where neural plasticity is required to accommodate movement control of both BMI and intact arm within a single hemisphere.
Neural adaptation with BMI exposure has shown single cell plasticity including changes in the tuning properties of individual neurons7, 8, 29. Synchrony in a specific bandwidth of neural oscillations has also been shown to increase with BMI exposure9. Likewise, with operant conditioning of a neuroprosthetic device, the coherence between neural activity in M1 and dorsal striatum has been shown to increase30. It was previously argued that plasticity at the subcortical levels is necessary to learn neuroprosthetic skills31. However, further studies would be needed to establish whether subcortical plasticity is critical also for chronic amputees acquiring neuroprosthetic skills and whether such plasticity have any causal influence on the cortical plasticity.
Decoder B. While Decoder A is more suitable for unilateral amputees capable of moving the ipsilateral arm, an unsupervised approach47 based on resting-state neural activity was tested that completely relaxes any requirement of motor behavior. This decoder uses spontaneous neural activity characteristics to estimate the decoder coefficients. Tap weights were sampled from a multivariate Gaussian generative model space denoted by,
But with her new prosthetics or graffiti, as she likes to call them, she's overcoming the steps as a double amputee. Making it to the top, nearly a mile straight up on abandoned railway ties has never felt so good.
Jane Koza, a 63-year-old paraplegic amputee, is living an inspirational life of struggle and success. Koza said she figured there was more to life than sitting in the lobby of the nursing home, which prompted her to leave.
Jose became a triple amputee after stepping on a bomb in Afghanistan. The doctors told his unit he wasn't going to make it. But he woke up from a coma ten days later. His road to recovery wasn't easy. In fact, odds were against him. He spent two years in the hospital after the explosion and was told he would never walk again. But this is Jose today, catching a wave with Ricochet to inspire other wounded warriors, as well as anyone else struggling through life.
New York Fashion Week is in full swing, and Daisy-May Demetre just made a big debut that will stand the test of time. Demetre is a 9-year-old double-amputee model who walked on the runway during the Lulu et Gigi show on Sunday. 1e1e36bf2d